Pakistan Is Heating Up

BBC NEWS | South Asia | Many killed in Pakistan bombing

And let's not forget that Pakistan is the one Islamic state with actual nuclear capability.

Losing the war in Afghanistan (because the administration was obsessed and distracted with Iraq) with the Taliban resurgent means possible spill-over/blowback into Pakistan, which set up the Taliban originally as a buffer between Iraq and Pakistan. Just as Al Qaeda is the illegitimate offspring of the Mujahadeen first trained, armed and financed by the CIA when Russia was occupying Afghanistan, the Taliban are the dogs of war released by the Pakistanis who may return to gnaw off the hands that fed them.